ESNPC

Roche Laboratories is warning about the danger of administering the antibiotic Rocephin (ceftriaxone sodium) along with IV products that contain calcium, such as parenteral nutrition, because harmful precipitates can occur.
The labeling describes cases of fatal reactions in neonates where precipitates were found in the infants’ lungs or kidneys. In some of these cases, the Rocephin [...]

FDA is updating earlier recommendations about the interaction between the antibiotic ceftriaxone and intravenous products that contain calcium. In certain circumstances, this interaction can cause dangerous precipitates to form. Ceftriaxone is sold as Rocephin and also as a generic. Products that contain calcium include Ringer’s solution, Hartmann’s solution and parenteral nutrition formulations that contain calcium.
FDA [...]